Animal papillomaviruses.

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Animal Papillomaviruses

Systematic studies as well as anecdotal observations suggest that all mammals, some (or all) birds, and probably some other vertebrates and even nonvertebrates are infected by papillomaviruses (PVs). Historically, these observations were made by pathology examination, electron microscopy, or immunohistochemistry with polyclonal antibodies against the highly conserved L1 protein. In the last 15 ...

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The immunology of animal papillomaviruses.

Papillomaviruses are species- and tissue-specific double-stranded DNA viruses. These viruses cause epithelial tumours in many animals, including man. Typically, the benign warts undergo spontaneous, immune-mediated regression, most likely effected by T-cells (especially CD4, but also CD8 subsets), whereas humoral immunity can prevent new infections. Some papillomavirus infections fail to regres...

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Papillomaviruses

Papillomaviruses (PVs) are a numerous family of small dsDNA viruses infecting virtually all mammals. PVs cause infections without triggering a strong immune response, and natural infection provides only limited protection against reinfection. Most PVs are part and parcel of the skin microbiota. In some cases, infections by certain PVs take diverse clinical presentations from highly productive s...

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Human PaPillomaviruses

The HPV genome is divided into three regions: the long control region (LCR), which regulates viral gene expression and replication; the early (E) region, which encodes proteins required for viral gene expression, replication and survival; and the late (L) region, which encodes the viral structural proteins. The designations E and L refer to the phase in the viral life cycle when these proteins ...

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Rodent Papillomaviruses

Preclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments. In this context, rodent papillomaviruses and their respective infection models are useful tools but remain underutilized resources in the field of papillomavirus biology. Two rodent papillomaviruses, MnPV1, which inf...

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ژورنال

عنوان ژورنال: Microbiological Reviews

سال: 1982

ISSN: 0146-0749

DOI: 10.1128/mmbr.46.2.191-207.1982